WP5 - Screening of point mutations in candidate gene targets by amplicon NGS and DNA enrichment approach

The main objectives of WP5 are focused on the identification of novel diagnostic, prognostic and MRD (minimal residual disease) follow-up biomarkers, and in particular are devoted to set up NGS amplicon-based and/or targeted DNA enrichment-based assays, to evaluate whether NGS is appropriate for routine screening of selected genes in a diagnostic setting, as well as to set up a NGS amplicon-based and/or targeted DNA enrichment-based assays for the validation of the most relevant novel molecular markers identified in the WP4.