WP6 - Identification of bone marrow and circulating miRNA and their association with clinical outcome

The main objectives of the WP6 are focused on the identification of reliable and informative miRNA-based biomarkers that can be medically valuable to provide relevant insights into the biology of BCR-ABL1-negative myeloproliferative neoplasms, BCR-ABL1-positive leukemias, AML, CLL and ALL, as well as that can improve early and non-invasive diagnosis and better disease classification for more effective anti-leukemias therapies.

Moreover, WP6 is aimed at identifying miRNAs that contribute to disease progression, therapy resistance and relapse.